• https://world-signals.com/news/2023/01/24/health-authorities-do-not-check-the-vaccination-status-of-mothers-of-dead-children-so-as-not-to-undermine-confidence-in-vaccines/
    Health authorities do not check the vaccination status of mothers of dead children so as not to undermine confidence in vaccines
    #news #scotland #politics #health #baby #child #vaccine #sideeffects #covid #covid19
    https://world-signals.com/news/2023/01/24/health-authorities-do-not-check-the-vaccination-status-of-mothers-of-dead-children-so-as-not-to-undermine-confidence-in-vaccines/ Health authorities do not check the vaccination status of mothers of dead children so as not to undermine confidence in vaccines #news #scotland #politics #health #baby #child #vaccine #sideeffects #covid #covid19
    1
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  • THE PHARMACEUTICAL INDUSTRY IS PRESENTLY EXPERIENCING A PROMINENT NEED FOR BIOAVAILABILITY ENHANCEMENT TECHNOLOGIES AND SERVICES
    Over the last couple of decades, the concept of bioavailability has garnered significant attention in the pharmaceutical industry. It is considered to be one of the most important pharmacokinetic properties of a drug. Bioavailability refers to the proportion of a drug that reaches systemic circulation unaltered, post dose administration. Additionally, it is a direct consequence of the absorption potential of an active pharmaceutical ingredient (API). The bioavailability of a drug is dependent on several factors, such as solubility, route of administration and metabolism of the drug post administration. The following figure provides different factors that have been reported to impact drug bioavailability either directly or indirectly. For this purpose, substantial mergers and acquisitions have been reported in this market, as service providers strive to become one-stop-shops, to cater to the diverse needs for their clientele. In addition, several stakeholders are engaged in the development of proprietary technologies, based on sustained release principle and bioavailability enhancers, to maintain a competitive edge in this rapidly emerging market. An increasing number of drug candidates have been granted approval via the 505(b)(2) pathway; the aforementioned pathway is used to gain approval for novel formulations consisting of previously approved active pharmaceutical ingredient (API). Additionally, given the shifting focus of drug developers towards development of lipophilic drug compounds, the industry is actively undertaking efforts to identify various bioavailability enhancement techniques, in order to mitigate the challenge of low bioavailability and stability.

    To request a sample copy / brochure of this report, please visit
    https://www.rootsanalysis.com/reports/198/request-sample.html

     Solubility: The solubility of a substance refers to its ability to dissolve in a solvent and form a homogeneous system. Drug solubility is considered to be one of the most important factors responsible for enabling a therapeutic intervention to be efficiently distributed via systemic circulation. It is worth highlighting that a drug’s solubility is directly proportional to its bioavailability and hence, is one of the primary parameters that is modified during bioavailability enhancement
     Permeability: Permeability refers to the ability of a molecule to pass through biological membranes. Similar to solubility, drug permeability plays a key role in its absorption and systemic distribution. Membrane based efflux mechanisms and other structural barriers are the major biological elements responsible for poor permeability of drugs. Permeability of a drug is also proportional to its bioavailability; however, it is possible to improve this characteristic by modifying the physiochemical properties of the drug to render them more suitable for absorption across different types of biological membranes.
     Molecule Size: Rate of absorption increases inversely with the size of a drug molecule. However, several studies have demonstrated that, absorption mechanisms vary significantly for different sizes of molecules. For instance, larger molecules get absorbed either by endocytosis or facilitated diffusion, whereas smaller molecules are absorbed via aqueous diffusion or through lipid channels.
     Degree of Ionization: Degree of ionization has a direct impact on drug absorption. Higher degree of ionization of a drug molecule results in poor solubility. As a general rule, basic drugs get ionized in acidic medium and are therefore, poorly soluble in acidic medium. The same rule applies to acidic drugs in basic medium.
     Formulation: The formulation process involves the addition of certain excipients, which are inactive substances that augment the properties of the drugs. Despite being inactive, these substances can influence drug bioavailability.
     Concentration: According to Fick’s law of diffusion, higher drug concentration in a tissue microenvironment, leads to higher flux through the membrane, resulting in a high rate of absorption.
     Dosage Forms: Drugs can be administered into the body via a number of routes, such as oral, transdermal, ocular and intramuscular. However, it is important to note that the mode of administration plays a very significant role in drug bioavailability. Several studies have demonstrated that only intravenous injections offer 100% drug availability in systemic circulation compared to any other route.
     Physical Forms: The physical form of the drug (solid, liquid or inhalable powder) also affects its rate of absorption. It is worth highlighting that drugs get more absorbed in gaseous form followed by liquid and solid form respectively.

     Chemical Nature: The chemical make-up of a drug is also an important determinant of its absorption potential and bioavailability. It has been observed that inorganic salts are more readily absorbed than organic compounds, when administered via the oral route.

    Further, given the rapid increase in the number of NCEs with low solubility and considering that this trend persists in the future as well, there is likely to be a surge in the demand for technologies that facilitate bioavailability enhancement. There are a number of technologies which are already available for improving drug bioavailability. Broadly these technologies can be distributed across three main categories, namely physical, chemical and biological approaches. However, as pharmacological interventions gradually become more complex and novel drug classes are introduced, further innovation may be required in the development of better bioavailability enhancement techniques / methods.

    For additional details, please visit
    https://www.rootsanalysis.com/reports/view_document/bioavailability-enhancement-technologies-and-services/198.html or email sales@rootsanalysis.com

    You may also be interested in the following titles:
    1. RNAi Market: Therapeutics and Technologies (Focus on siRNA, miRNA, shRNA and DNA) (3rd Edition): Industry Trends and Global Forecasts, 2022-2035
    2. Global Therapeutic Vaccines Market: Industry Trends and Global Forecasts, 2022-2035

    About Roots Analysis
    Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

    Contact:
    Ben Johnson
    +1 (415) 800 3415
    Ben.johnson@rootsanalysis.com



    THE PHARMACEUTICAL INDUSTRY IS PRESENTLY EXPERIENCING A PROMINENT NEED FOR BIOAVAILABILITY ENHANCEMENT TECHNOLOGIES AND SERVICES Over the last couple of decades, the concept of bioavailability has garnered significant attention in the pharmaceutical industry. It is considered to be one of the most important pharmacokinetic properties of a drug. Bioavailability refers to the proportion of a drug that reaches systemic circulation unaltered, post dose administration. Additionally, it is a direct consequence of the absorption potential of an active pharmaceutical ingredient (API). The bioavailability of a drug is dependent on several factors, such as solubility, route of administration and metabolism of the drug post administration. The following figure provides different factors that have been reported to impact drug bioavailability either directly or indirectly. For this purpose, substantial mergers and acquisitions have been reported in this market, as service providers strive to become one-stop-shops, to cater to the diverse needs for their clientele. In addition, several stakeholders are engaged in the development of proprietary technologies, based on sustained release principle and bioavailability enhancers, to maintain a competitive edge in this rapidly emerging market. An increasing number of drug candidates have been granted approval via the 505(b)(2) pathway; the aforementioned pathway is used to gain approval for novel formulations consisting of previously approved active pharmaceutical ingredient (API). Additionally, given the shifting focus of drug developers towards development of lipophilic drug compounds, the industry is actively undertaking efforts to identify various bioavailability enhancement techniques, in order to mitigate the challenge of low bioavailability and stability. To request a sample copy / brochure of this report, please visit https://www.rootsanalysis.com/reports/198/request-sample.html  Solubility: The solubility of a substance refers to its ability to dissolve in a solvent and form a homogeneous system. Drug solubility is considered to be one of the most important factors responsible for enabling a therapeutic intervention to be efficiently distributed via systemic circulation. It is worth highlighting that a drug’s solubility is directly proportional to its bioavailability and hence, is one of the primary parameters that is modified during bioavailability enhancement  Permeability: Permeability refers to the ability of a molecule to pass through biological membranes. Similar to solubility, drug permeability plays a key role in its absorption and systemic distribution. Membrane based efflux mechanisms and other structural barriers are the major biological elements responsible for poor permeability of drugs. Permeability of a drug is also proportional to its bioavailability; however, it is possible to improve this characteristic by modifying the physiochemical properties of the drug to render them more suitable for absorption across different types of biological membranes.  Molecule Size: Rate of absorption increases inversely with the size of a drug molecule. However, several studies have demonstrated that, absorption mechanisms vary significantly for different sizes of molecules. For instance, larger molecules get absorbed either by endocytosis or facilitated diffusion, whereas smaller molecules are absorbed via aqueous diffusion or through lipid channels.  Degree of Ionization: Degree of ionization has a direct impact on drug absorption. Higher degree of ionization of a drug molecule results in poor solubility. As a general rule, basic drugs get ionized in acidic medium and are therefore, poorly soluble in acidic medium. The same rule applies to acidic drugs in basic medium.  Formulation: The formulation process involves the addition of certain excipients, which are inactive substances that augment the properties of the drugs. Despite being inactive, these substances can influence drug bioavailability.  Concentration: According to Fick’s law of diffusion, higher drug concentration in a tissue microenvironment, leads to higher flux through the membrane, resulting in a high rate of absorption.  Dosage Forms: Drugs can be administered into the body via a number of routes, such as oral, transdermal, ocular and intramuscular. However, it is important to note that the mode of administration plays a very significant role in drug bioavailability. Several studies have demonstrated that only intravenous injections offer 100% drug availability in systemic circulation compared to any other route.  Physical Forms: The physical form of the drug (solid, liquid or inhalable powder) also affects its rate of absorption. It is worth highlighting that drugs get more absorbed in gaseous form followed by liquid and solid form respectively.  Chemical Nature: The chemical make-up of a drug is also an important determinant of its absorption potential and bioavailability. It has been observed that inorganic salts are more readily absorbed than organic compounds, when administered via the oral route. Further, given the rapid increase in the number of NCEs with low solubility and considering that this trend persists in the future as well, there is likely to be a surge in the demand for technologies that facilitate bioavailability enhancement. There are a number of technologies which are already available for improving drug bioavailability. Broadly these technologies can be distributed across three main categories, namely physical, chemical and biological approaches. However, as pharmacological interventions gradually become more complex and novel drug classes are introduced, further innovation may be required in the development of better bioavailability enhancement techniques / methods. For additional details, please visit https://www.rootsanalysis.com/reports/view_document/bioavailability-enhancement-technologies-and-services/198.html or email sales@rootsanalysis.com You may also be interested in the following titles: 1. RNAi Market: Therapeutics and Technologies (Focus on siRNA, miRNA, shRNA and DNA) (3rd Edition): Industry Trends and Global Forecasts, 2022-2035 2. Global Therapeutic Vaccines Market: Industry Trends and Global Forecasts, 2022-2035 About Roots Analysis Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. Contact: Ben Johnson +1 (415) 800 3415 Ben.johnson@rootsanalysis.com
    Request Sample - Bioavailability Enhancement Technologies and Services | Market Size | 2035
    The space of bioavailability enhancement technologies and services, driven by the increase in number of BCS II and BCS IV molecules in early phases of development, is likely to grow at CAGR of ~11%, till 2035
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  • https://world-signals.com/news/2023/01/14/instructions-from-the-who-for-doctors-and-politicians-in-favor-of-vaccines-precise-instructions-in-case-of-death-of-a-child/
    Instructions from the WHO for doctors and politicians in favor of vaccines, precise instructions in case of death of a child
    #news #who #politics #usa #america #vaccine #covid #covid19
    https://world-signals.com/news/2023/01/14/instructions-from-the-who-for-doctors-and-politicians-in-favor-of-vaccines-precise-instructions-in-case-of-death-of-a-child/ Instructions from the WHO for doctors and politicians in favor of vaccines, precise instructions in case of death of a child #news #who #politics #usa #america #vaccine #covid #covid19
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  • https://holistichealth.one/zeolite-pure-information If you live on this heavily vaxxed planet you need protection against the vax shedders and spreaders not coronaviruses (common flu viruses.) Zeolite is a natural crystal mineral that is highly alkaline and has the unique ability to trap toxins including pathogens in it's honeycomb structure and eliminate it through normal eliminations as it can't be absorbed. It protects You and Your Family from from airborne microbes like bacteria and pathogens like the covid-19 naturally. It also is the number one detox from vaccines (like the covid vaccines with heavy metals and parasites), radiation and heavy metals and is a natural anti-cancer remedy (even helps against the treatment side effects of radiation and chemotherapy.) A properly boosted immune system can stop any and all viruses, period! Do not fear it, prepare your immune system to detect and defeat it naturally. #zeolite #antiviral #covid-19 #parasites #detox
    https://holistichealth.one/zeolite-pure-information If you live on this heavily vaxxed planet you need protection against the vax shedders and spreaders not coronaviruses (common flu viruses.) Zeolite is a natural crystal mineral that is highly alkaline and has the unique ability to trap toxins including pathogens in it's honeycomb structure and eliminate it through normal eliminations as it can't be absorbed. It protects You and Your Family from from airborne microbes like bacteria and pathogens like the covid-19 naturally. It also is the number one detox from vaccines (like the covid vaccines with heavy metals and parasites), radiation and heavy metals and is a natural anti-cancer remedy (even helps against the treatment side effects of radiation and chemotherapy.) A properly boosted immune system can stop any and all viruses, period! Do not fear it, prepare your immune system to detect and defeat it naturally. #zeolite #antiviral #covid-19 #parasites #detox
    1
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  • https://world-signals.com/news/2022/12/28/already-100-years-ago-the-human-body-will-be-treated-at-birth-through-vaccines/
    Already 100 years ago: The human body will be treated at birth through vaccines
    #news #history #vaccine #medicine #health #children
    https://world-signals.com/news/2022/12/28/already-100-years-ago-the-human-body-will-be-treated-at-birth-through-vaccines/ Already 100 years ago: The human body will be treated at birth through vaccines #news #history #vaccine #medicine #health #children
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  • https://world-signals.com/news/2022/12/24/whats-in-childrens-vaccines/
    What's in Children's Vaccines?
    #news #usa #america #vaccine #children #mrna
    https://world-signals.com/news/2022/12/24/whats-in-childrens-vaccines/ What's in Children's Vaccines? #news #usa #america #vaccine #children #mrna
    1
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  • https://world-signals.com/news/2022/12/22/the-only-thing-gene-vaccines-can-do-is/
    The only thing gene vaccines can do is…
    #news #usa #america #vaccine #health #sideeffects #bhakdi
    https://world-signals.com/news/2022/12/22/the-only-thing-gene-vaccines-can-do-is/ The only thing gene vaccines can do is… #news #usa #america #vaccine #health #sideeffects #bhakdi
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  • https://berkeywaterfilter.us/all-berkey-water-filter-unitsBest U.S. Made Portable Water Filter - Be Prepared and Have Clean Drinking Water. Support Fellow Americans First and Veterans and Buy American! The number one most important thing to your survival is clean air and uncontaminated drinking water. People taking vaxxes are shedding through urination into the waste system, and tap water recycling doesn't get rid of all the toxins in it from Covid-19 vaccines. Make Sure you have access to fluoride, lead, mercury, microbe and viral contaminant free drinking water in any emergency. Berkey U.S. water purifiers are the number one portable water purification system in the world! Always be safe from any emergency, water or power shut-off or outbreak. #berkey #purification #water #filter #prepping
    https://berkeywaterfilter.us/all-berkey-water-filter-unitsBest U.S. Made Portable Water Filter - Be Prepared and Have Clean Drinking Water. Support Fellow Americans First and Veterans and Buy American! The number one most important thing to your survival is clean air and uncontaminated drinking water. People taking vaxxes are shedding through urination into the waste system, and tap water recycling doesn't get rid of all the toxins in it from Covid-19 vaccines. Make Sure you have access to fluoride, lead, mercury, microbe and viral contaminant free drinking water in any emergency. Berkey U.S. water purifiers are the number one portable water purification system in the world! Always be safe from any emergency, water or power shut-off or outbreak. #berkey #purification #water #filter #prepping
    1
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  • RNAi THERAPY OFFERS THE POTENTIAL TO REVOLUTIONIZE THE BIOPHARMACEUTICAL INDUSTRY

    Owing to their vast potential in controlling disease-associated gene expression, RNAi therapeutics have emerged as a key segment of the market; several big pharma players have undertaken RNAi focused initiatives.

    In addition to effective gene silencing, these candidates can be deployed for applications related to precision medicine. Studies have also demonstrated the safety of RNAi therapeutics for in systemic delivery, paving the way for systemic applications of the therapy. A number of novel and sophisticated technologies / platforms have been / are being developed to overcome the challenges associated with RNAi therapeutics, as well as further enhance their specificity and stability. Further, considering their high knockdown efficiency, high target specificity and extended silencing ability, RNAi has now been established as a powerful tool for gene silencing. It is worth highlighting, RNAi has potential applications in treating several viral infections and tumors in addition to its ability in gene function determination. However, despite the numerous benefits offered by RNAi therapies, developers often face concerns related to the stability and targeted delivery of their candidates. In order to mitigate the aforementioned challenges, several players have developed novel technologies and delivery systems to ensure target specific delivery of these molecules.

    To request a sample copy / brochure of this report, please visit
    https://www.rootsanalysis.com/reports/278/request-sample.html

    With four approved drugs and several therapy candidates being evaluated in late stages of clinical development, the RNAi therapeutics domain presents a significant opportunity for biopharmaceutical developers. In addition, a number of RNAi therapeutics are being developed to target rare and genetic clinical conditions, such as Alpha 1-Antitrypsin Disease, Alport Syndrome, Amyloidosis and Muscular Dystrophy (Facioscapulohumeral Muscular Dystrophy and Oculopharyngeal Muscular Dystrophy). It is also worth highlighting that over 2,100 patents have been filed / granted, highlighting the continuous pace of ongoing innovation in this field. Given the high research activity and ongoing technology advancements, the RNAi therapeutics market is poised to grow at a steady pace in the foreseen future. An insightful technology competitiveness analysis, benchmarking RNAi technologies, based on supplier power (in terms of company size and years of experience) and key technology specifications. The analysis was designed to enable stakeholder companies to compare their existing capabilities within and beyond their respective peer groups and identify opportunities to achieve a competitive edge in the industry.



    For additional details please visit https://www.rootsanalysis.com/reports/view_document/rnai-therapeutics-market/278.html or email sales@rootsanalysis.com

    You may also be interested in the following titles:
    1. Targeted protein degradation market, 2022-2035
    2. Global Therapeutic Vaccines Market: Industry Trends and Global Forecasts, 2022-2035

    About Roots Analysis
    Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

    Contact:
    Ben Johnson
    +1 (415) 800 3415
    +44 (122) 391 1091
    Ben.johnson@rootsanalysis.com

    RNAi THERAPY OFFERS THE POTENTIAL TO REVOLUTIONIZE THE BIOPHARMACEUTICAL INDUSTRY Owing to their vast potential in controlling disease-associated gene expression, RNAi therapeutics have emerged as a key segment of the market; several big pharma players have undertaken RNAi focused initiatives. In addition to effective gene silencing, these candidates can be deployed for applications related to precision medicine. Studies have also demonstrated the safety of RNAi therapeutics for in systemic delivery, paving the way for systemic applications of the therapy. A number of novel and sophisticated technologies / platforms have been / are being developed to overcome the challenges associated with RNAi therapeutics, as well as further enhance their specificity and stability. Further, considering their high knockdown efficiency, high target specificity and extended silencing ability, RNAi has now been established as a powerful tool for gene silencing. It is worth highlighting, RNAi has potential applications in treating several viral infections and tumors in addition to its ability in gene function determination. However, despite the numerous benefits offered by RNAi therapies, developers often face concerns related to the stability and targeted delivery of their candidates. In order to mitigate the aforementioned challenges, several players have developed novel technologies and delivery systems to ensure target specific delivery of these molecules. To request a sample copy / brochure of this report, please visit https://www.rootsanalysis.com/reports/278/request-sample.html With four approved drugs and several therapy candidates being evaluated in late stages of clinical development, the RNAi therapeutics domain presents a significant opportunity for biopharmaceutical developers. In addition, a number of RNAi therapeutics are being developed to target rare and genetic clinical conditions, such as Alpha 1-Antitrypsin Disease, Alport Syndrome, Amyloidosis and Muscular Dystrophy (Facioscapulohumeral Muscular Dystrophy and Oculopharyngeal Muscular Dystrophy). It is also worth highlighting that over 2,100 patents have been filed / granted, highlighting the continuous pace of ongoing innovation in this field. Given the high research activity and ongoing technology advancements, the RNAi therapeutics market is poised to grow at a steady pace in the foreseen future. An insightful technology competitiveness analysis, benchmarking RNAi technologies, based on supplier power (in terms of company size and years of experience) and key technology specifications. The analysis was designed to enable stakeholder companies to compare their existing capabilities within and beyond their respective peer groups and identify opportunities to achieve a competitive edge in the industry. For additional details please visit https://www.rootsanalysis.com/reports/view_document/rnai-therapeutics-market/278.html or email sales@rootsanalysis.com You may also be interested in the following titles: 1. Targeted protein degradation market, 2022-2035 2. Global Therapeutic Vaccines Market: Industry Trends and Global Forecasts, 2022-2035 About Roots Analysis Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. Contact: Ben Johnson +1 (415) 800 3415 +44 (122) 391 1091 Ben.johnson@rootsanalysis.com
    Request Sample - RNAi Therapeutics and Technologies Market | Industry Analysis | Market Size | 2035
    The RNAi market: Therapeutics and Technologies features an extensive study of the current market landscape and the likely future potential; associated with the RNAi therapeutics market....
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  • https://arthritistreatment.one/heal-soothe-pain-relief-anti-inflammatory Stop taking dangerous pharma (particularly covid-19 related vaccines as they are causing autoimmune issues like rheumatoid arthritis.) They never heal or cure your arthritis only cause more joint destruction and a compromised immune system. Natural Arthritis Remedies stop your arthritis and joint pain without harmful side effects. It can also help you reverse your arthritis by healing the joint tissue damage and creating a smooth arthritis free joint. Restores range of motion without pain. Not just a Band-Aid but true healing from mother nature! #arthritis #rheumatoid #covid -19 #inflammation #health
    https://arthritistreatment.one/heal-soothe-pain-relief-anti-inflammatory Stop taking dangerous pharma (particularly covid-19 related vaccines as they are causing autoimmune issues like rheumatoid arthritis.) They never heal or cure your arthritis only cause more joint destruction and a compromised immune system. Natural Arthritis Remedies stop your arthritis and joint pain without harmful side effects. It can also help you reverse your arthritis by healing the joint tissue damage and creating a smooth arthritis free joint. Restores range of motion without pain. Not just a Band-Aid but true healing from mother nature! #arthritis #rheumatoid #covid -19 #inflammation #health
    1
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